Reyataz - Bristol-myers
These patents cover the drug REYATAZ. It is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS).
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The active ingredient of REYATAZ is atazanavir sulfate.
The patents relate to the structure, compositions, formulations and methods of use of atazanavir sulfate.
Name of Substance
2,5,6,10,13-Pentaazatetradecanedioic acid, 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-((4-(2-pyridinyl)phenyl)methyl)-, dimethyl ester,
(3S,8S,9S,12S)-2,5,6,10,13-Pentaazatetradecanedioic acid, 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-((4-(2-pyridinyl)phenyl)methyl)-, dimethyl ester, (3S-(3R*,8R*,9R*,12R*))-
In allowing the claims of the â€˜911 patent, the examiner wrote:
â€œClaims 1-11 are allowed. The closest prior art is Fassler et al. (J. Med. Chem. 1996, vol. 39, pages 3203-3216) disclose aza-peptide analogs as potent Human Immunodeficiency Virus Type-1 Protease Inhibitors with oral bioavailability.
The instant claims differ from the reference in having the substituted phenyl group at R4 position, whereas the reference teach [sic] unsubstituted phenyl group at the same position. This difference was neither taught or suggested by the prior art of record.â€
See the claims in the downloadable copies of the patents.
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