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Reyataz - Bristol-myers

Study ID: 308
Research Type: Validity
Expiration Date: 2010-01-04

These patents cover the drug REYATAZ. It is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS).

Completed 2010-01-04
Reward $20,000

The active ingredient of REYATAZ is atazanavir sulfate.

The patents relate to the structure, compositions, formulations and methods of use of atazanavir sulfate.
Name of Substance
Atazanavir [INN:BAN]
BMS 232632

CGP 73547
HSDB 7339

Systematic Name
2,5,6,10,13-Pentaazatetradecanedioic acid, 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-((4-(2-pyridinyl)phenyl)methyl)-, dimethyl ester,
(3S,8S,9S,12S)-2,5,6,10,13-Pentaazatetradecanedioic acid, 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-((4-(2-pyridinyl)phenyl)methyl)-, dimethyl ester, (3S-(3R*,8R*,9R*,12R*))-

In allowing the claims of the ‘911 patent, the examiner wrote:
“Claims 1-11 are allowed. The closest prior art is Fassler et al. (J. Med. Chem. 1996, vol. 39, pages 3203-3216) disclose aza-peptide analogs as potent Human Immunodeficiency Virus Type-1 Protease Inhibitors with oral bioavailability.
The instant claims differ from the reference in having the substituted phenyl group at R4 position, whereas the reference teach [sic] unsubstituted phenyl group at the same position. This difference was neither taught or suggested by the prior art of record.” 

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See the claims in the downloadable copies of the patents.

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