Reyataz - Bristol-myers
These patents cover the drug REYATAZ. It is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS).
The active ingredient of REYATAZ is atazanavir sulfate.
The patents relate to the structure, compositions, formulations and methods of use of atazanavir sulfate.
Name of Substance
2,5,6,10,13-Pentaazatetradecanedioic acid, 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-((4-(2-pyridinyl)phenyl)methyl)-, dimethyl ester,
(3S,8S,9S,12S)-2,5,6,10,13-Pentaazatetradecanedioic acid, 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-((4-(2-pyridinyl)phenyl)methyl)-, dimethyl ester, (3S-(3R*,8R*,9R*,12R*))-
In allowing the claims of the â€˜911 patent, the examiner wrote:
â€œClaims 1-11 are allowed. The closest prior art is Fassler et al. (J. Med. Chem. 1996, vol. 39, pages 3203-3216) disclose aza-peptide analogs as potent Human Immunodeficiency Virus Type-1 Protease Inhibitors with oral bioavailability.
The instant claims differ from the reference in having the substituted phenyl group at R4 position, whereas the reference teach [sic] unsubstituted phenyl group at the same position. This difference was neither taught or suggested by the prior art of record.â€